Mucuna Supreme is made from the seeds of the velvet-bean, Mucuna pruriens, which is native to tropical and subtropical regions. It has been used as a green cover-crop and livestock forage due to the high protein content of its seeds (1). Mucunas use as a medicinal plant dates back thousands of years. It been used to treat a wide variety of conditions including high blood pressure, low sperm count, low libido, male infertility, diabetes, and neurodegenerative conditions like Parkinsons disease, and has been shown to have marked antioxidant activity (2). Mucuna has marked ACE inhibiting properties, making its action similar to some pharmaceutical drugs designed to lower blood pressure (3). There are many studies showing the positive effects of Mucuna on increasing sperm count and sperm motility (4, 5), as well as helping normalize healthy libido (6, 7) and helping treat male infertility (8, 9, 10, 11). Mucuna also has some promising research in treating erectile dysfunction in men (12). Some of Mucunas most famous effects are on the dopaminergic centers of the brain. Mucuna contains 4-7% L-Dopa which is the immediate precursor to Dopamine (13). Dopamine is an important neurotransmitter that helps people to feel a sense of satiety and contentment. When people feel a greater sense of contentment and connectedness, they tend to have less anxiety and can side-step stress more effectively. Mucuna has been shown in countless studies to raise dopamine levels in the brain. Parkinsons disease is a condition where the dopamine producing centers of the brain are damaged and not enough dopamine is produced. These patients are often treated with dopamine-enhancing drugs like Levodopa, often with diffi cult side effects. Patients who take Mucuna, however, get the benefi t of the dopamine producing effects of Mucuna but without many of the diffi cult side effects of these pharmaceuticals (14, 15). The L-Dopa content may also be used to help those suffering from depression (16). The L-Dopa found in mucuna can also be converted into epinephrine, helping those suffering from fatigue. In addition to Parkinsons disease, Mucuna has been studied for other movement disorders like Epilepsy, and initial research has shown positive benefi ts (17). Mucuna has been shown to have anti-parasitic activity (18) as well as anti-neoplastic activities against liver cancer (19). Additionally there have been several studies showing that Mucuna has the ability to lower blood sugar and so its use has been proposed to helping treat diabetes and insulin resistance (20, 21, 22, 23, 24). Safety Caution in patients with a personal or family history of melanoma and patients with a personal history of low blood sugar (hypoglycemia). Also Mucuna helps lower blood pressure, so it is not recommended in patients with low blood pressure. Additionally there is minimal safety data on Pregnancy and Lactation so Mucuna is best avoided during these times. Dosage One cap on awakening, at least 30 minutes before food. Two caps may be needed but ask your physician before increasing. Do not go off of your prescribed Parkinsons drugs and replace them with Macuna. There have not been enough studies to support this. Always work with your physician to utilize their expertise.