N-Acetyl-L-Cysteine (NAC) is an amino acid that supports detoxification, reduces oxidative stress, and helps stabilize blood sugar. NAC aids the body’s phase II detoxification pathways, glutathione conjugation and sulphation. By providing the limiting factor in glutathione synthesis, NAC helps to restore intracellular glutathione levels. Since NAC plays a major role in detoxification, it may offer protection against daily exposure to environmental contaminants and toxins. *
- Promotes healthy glutathione levels*
- Supports detoxification pathways*
- Helps loosen and clear mucus*
Each size 0 vegetarian cellulose capsule contains:
N-Acetyl-L-Cysteine (NAC) is an amino acid that supports detoxification, reduces oxidative stress, and helps stabilize blood sugar. NAC aids the body’s phase II detoxification pathways, glutathione conjugation, and sulphation. By providing the limiting factor in glutathione synthesis, NAC helps to restore intracellular glutathione levels. Since NAC plays a major role in detoxification, it may offer protection against daily exposure to environmental contaminants and toxins.
What is NAC?
NAC is not found in food but is a specially-derived form of the sulfur-containing amino acid L-cysteine. NAC is more stable than L-cysteine and may be better absorbed. NAC is mucolytic and hepatoprotective with significant antioxidant activity.
How does NAC Work?
NAC supports respiratory health by reducing disulfide bonds in mucoproteins. Since the 1960’s it has been known as a “mucolytic”, meaning it can cause reduced viscosity or thinning of mucus, making it easier to expel .
On a completely unrelated note, NAC has historically been used to treat acetaminophen overdose, as a powerful agent for liver detoxification. It functions by replenishing and substituting for GSH, a tripeptide made up of residues of amino acids glutamine, glycine, and cysteine . Although GSH plays a major role in the cellular detoxification pathway and is involved in the detoxification of most endogenous and exogenous toxicants, it is often deficient in people who are immunocompromised for various reasons . As a substitute/contributor to GSH availability, NAC aids the body’s Phase II detoxification pathways, glutathione conjugation, and sulfation, which rid the body of environmental contaminants and toxins.
NAC has antioxidant capabilities, both on its own and as the precursor for the important antioxidant L-glutathione . NAC helps to restore intracellular glutathione levels, protecting tissues from peroxidation and supporting normal immune function .
NAC exerts a sensitizing effect on both the insulin secretion of pancreatic cells and on insulin receptors on human red blood cells . This fact, in combination with the data showing NAC appears to have a protective effect on the ovary and preventive action against follicular atresia, has made NAC a suggested nutritional supplement for many women experiencing infertility due to polycystic ovarian syndrome (PCOS) .
What is the Suggested Use for NAC?
· Promotes healthy glutathione levels. Fight free radicals and cellular damage with this powerful antioxidant. Glutathione is also an immune booster!
· Supports detoxification pathways. Boost GSH activity to flush toxins from the body.
· Helps loosen and clear mucus. Due to its mucolytic activity, NAC can be helpful for excessive and/or thick mucus production.
· Improved insulin sensitivity and hormonal balance. May help to improve lipid profiles, fasting blood sugar, and fasting blood insulin levels, improve hormonal profiles, and aid in regulating ovulation and fertility in hyperinsulinemic patients with PCOS [4,5].
Source Materials: Cellulose for capsules is derived from softwood tree pulp. All ingredients are non-GMO.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.
Recommendations: One (1) capsule daily, or as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
1. Sheffer AL. The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent, N-acetyl-L-cysteine. Ann N Y Acad Sci 1963;106:298-310.
2. Bobb, Andrew J., Darryl P. Arfsten, and Warren W. Jederberg. "N-acetyl-L-Cysteine as prophylaxis against sulfur mustard." Military medicine 170.1 (2005): 52-56.
3. Mata, Manuel, et al. "N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)." Biochemical pharmacology 82.5 (2011): 548-555.
4. Badawy, Ahmed, Omnia State, and Soma Abdelgawad. "N‐Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross‐over trial." Acta obstetricia et gynecologica Scandinavica 86.2 (2007): 218-222.
5. Javanmanesh, Forough, et al. "A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine characteristics of women with polycystic ovary syndrome." Gynecological Endocrinology 32.4 (2016): 285-289.
* These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.